import tkinter import customtkinter # <- import the CustomTkinter module customtkinter.set_appearance_mode("System") # Other: "Dark", "Light" root_tk = customtkinter.CTk() # create CTk window like you do with the Tk window (you can also use normal tkinter.Tk window) root_tk.geometry("400x240") root_tk.title("CustomTkinter Test") def change_button_2_state(): if button_2.state == tkinter.NORMAL: button_2.configure(state=tkinter.DISABLED) elif button_2.state == tkinter.DISABLED: button_2.configure(state=tkinter.NORMAL) def button_2_click(): print("button_2 clicked") frame_1 = customtkinter.CTkFrame(master=root_tk, width=300, height=200, corner_radius=15) frame_1.place(relx=0.5, rely=0.5, anchor=tkinter.CENTER) button_1 = customtkinter.CTkButton(master=frame_1, text="Disable/Enable Button_2", corner_radius=10, command=change_button_2_state, width=200) button_1.place(relx=0.5, rely=0.3, anchor=tkinter.CENTER) button_2 = customtkinter.CTkButton(master=frame_1, text="Button_2", corner_radius=10, command=button_2_click) button_2.place(relx=0.5, rely=0.7, anchor=tkinter.CENTER) root_tk.mainloop()