diff --git a/vlib/v/gen/cgen.v b/vlib/v/gen/cgen.v
index af7f840bd2..caedad1108 100644
--- a/vlib/v/gen/cgen.v
+++ b/vlib/v/gen/cgen.v
@@ -41,6 +41,8 @@ const (
 		'class',
 		'typename'
 	]
+	cmp_str = ['eq', 'ne', 'gt', 'lt', 'ge', 'le'] // same order as in token.Kind
+	cmp_rev = ['eq', 'ne', 'le', 'ge', 'lt', 'gt'] // when operands are switched
 )
 
 struct Gen {
@@ -1688,11 +1690,21 @@ fn (mut g Gen) infix_expr(node ast.InfixExpr) {
 	// g.infix_op = node.op
 	left_type := if node.left_type == table.t_type { g.cur_generic_type } else { node.left_type }
 	left_sym := g.table.get_type_symbol(left_type)
+	unaliased_left := if left_sym.kind == .alias {
+		(left_sym.info as table.Alias).parent_typ
+	} else {
+		left_type
+	}
 	if node.op in [.key_is, .not_is] {
 		g.is_expr(node)
 		return
 	}
 	right_sym := g.table.get_type_symbol(node.right_type)
+	unaliased_right := if right_sym.kind == .alias {
+		(right_sym.info as table.Alias).parent_typ
+	} else {
+		node.right_type
+	}
 	if left_type == table.ustring_type_idx && node.op != .key_in && node.op != .not_in {
 		fn_name := match node.op {
 			.plus {
@@ -1837,6 +1849,20 @@ fn (mut g Gen) infix_expr(node ast.InfixExpr) {
 			}
 			g.write(' }))')
 		}
+	} else if unaliased_left.idx() in [table.u32_type_idx, table.u64_type_idx] && unaliased_right.is_signed() && node.op in [.eq, .ne, .gt, .lt, .ge, .le] {
+		bitsize := if unaliased_left.idx() == table.u32_type_idx && unaliased_right.idx() != table.i64_type_idx { 32 } else { 64 }
+		g.write('_us${bitsize}_${cmp_str[int(node.op)-int(token.Kind.eq)]}(')
+		g.expr(node.left)
+		g.write(',')
+		g.expr(node.right)
+		g.write(')')
+	} else if unaliased_right.idx() in [table.u32_type_idx, table.u64_type_idx] && unaliased_left.is_signed() && node.op in [.eq, .ne, .gt, .lt, .ge, .le] {
+		bitsize := if unaliased_right.idx() == table.u32_type_idx && unaliased_left.idx() != table.i64_type_idx { 32 } else { 64 }
+		g.write('_us${bitsize}_${cmp_rev[int(node.op)-int(token.Kind.eq)]}(')
+		g.expr(node.right)
+		g.write(',')
+		g.expr(node.left)
+		g.write(')')
 	} else {
 		a := left_sym.name[0].is_capital() || left_sym.name.contains('.')
 		b := left_sym.kind != .alias
diff --git a/vlib/v/gen/cheaders.v b/vlib/v/gen/cheaders.v
index 34637ddaae..9d804506d5 100644
--- a/vlib/v/gen/cheaders.v
+++ b/vlib/v/gen/cheaders.v
@@ -211,6 +211,21 @@ void* g_live_info = NULL;
 #define _IN(typ, val, arr) array_##typ##_contains(arr, val)
 #define _IN_MAP(val, m) map_exists(m, val)
 
+// unsigned/signed comparisons
+
+static inline bool _us32_gt(uint32_t a, int32_t b) { return a > INT32_MAX || (int32_t)a > b; }
+static inline bool _us32_ge(uint32_t a, int32_t b) { return a >= INT32_MAX || (int32_t)a >= b; }
+static inline bool _us32_eq(uint32_t a, int32_t b) { return a <= INT32_MAX && (int32_t)a == b; }
+static inline bool _us32_ne(uint32_t a, int32_t b) { return a > INT32_MAX || (int32_t)a != b; }
+static inline bool _us32_le(uint32_t a, int32_t b) { return a <= INT32_MAX && (int32_t)a <= b; }
+static inline bool _us32_lt(uint32_t a, int32_t b) { return a < INT32_MAX && (int32_t)a < b; }
+static inline bool _us64_gt(uint64_t a, int64_t b) { return a > INT64_MAX || (int64_t)a > b; }
+static inline bool _us64_ge(uint64_t a, int64_t b) { return a >= INT64_MAX || (int64_t)a >= b; }
+static inline bool _us64_eq(uint64_t a, int64_t b) { return a <= INT64_MAX && (int64_t)a == b; }
+static inline bool _us64_ne(uint64_t a, int64_t b) { return a > INT64_MAX || (int64_t)a != b; }
+static inline bool _us64_le(uint64_t a, int64_t b) { return a <= INT64_MAX && (int64_t)a <= b; }
+static inline bool _us64_lt(uint64_t a, int64_t b) { return a < INT64_MAX && (int64_t)a < b; }
+
 #if defined(__MINGW32__) || defined(__MINGW64__)
 #undef PRId64
 #undef PRIi64
diff --git a/vlib/v/tests/int_cmp_test.v b/vlib/v/tests/int_cmp_test.v
new file mode 100644
index 0000000000..3032f43bd7
--- /dev/null
+++ b/vlib/v/tests/int_cmp_test.v
@@ -0,0 +1,22 @@
+fn test_cmp_signed() {
+	assert i8(3) > i16(-10)
+	assert i16(-9) > int(-11)
+	assert i64(-12) <= i8(-12)
+	assert i64(-43232554) < i8(-126)
+}
+
+fn test_cmp_unsigned() {
+	assert byte(3) < u16(10)
+	assert u16(40000) > u32(200)
+	assert u64(18161419857654944321) >= byte(12)
+	assert u64(40000) < u16(40001)
+}
+
+fn test_cmp_unsigned_signed() {
+	assert byte(12) > i8(-12)
+	assert i16(-27) < u32(65463356)
+	assert u32(8543) > int(-7523)
+	assert i64(-89) <= u64(567)
+	assert int(-1) != u32(0xffffffff)
+	assert !(u64(0xfffffffffffffffe) == i64(-2))
+}